In most series, all phyllodes tumors may recur, but only the borderline and malignant phyllodes tumors metastasize. Phyllodes tumors follow up care by jonas wilson, ing. These biphasic tumors combine a doublelayered benign epithelial component epithelial and myoepithelial cells and an overgrowing. It can be difficult to tell the difference between a benign phyllodes tumor and a fibroadenoma, which is the most common type of benign breast tumor. Biopsy of the tumor was performed and showed a sarcomatous proliferation consistent with metastatic malignant phyllodes tumor. They usually occur in middleaged to elderly women but can occur at any age. A phyllodes tumour is a growth of cells that forms a hard lump in the breast. The term cystosarcoma phyllodes was coined by johannes muller in 1838 to describe the gross appearance of this cystic, fleshy, leafy, tumor of the breast, which he clearly stated to be a benign tumor. A diagnosis of phyllodes tumor may be favored clinically if the tumor size measures more than 4 cm with history of rapid growth. The epithelioid nests of this tumor may merge with spindle stromal elements. Synchronous malignant phyllodes tumor with skin ulceration and. Phyllodes tumors of the breast are rare fibroepithelial lesions that comprise less than 1% of all breast malignancies.
The positive predictive value of core needle biopsy was 83%. Surgical management of phyllodes tumors oncology jama. Last month i had a partial mastectomy for a highgrade malignant phyllodes tumor. Usia pasien adalah 1090 tahun namun yang terbanyak adalah pada kelompok usia 35 55tahun haagensens series. It is typically a large, bulky tumor, and tends to have multiple smaller satellites that extend beyond the main confines of the tumor.
Phyllodes tumor is a rare fibroepithelial neoplasm of the breast, with unpredictable clinical behavior. The tumor is rarely found in adolescents and the elderly. Liposarcoma is a cancer that arises in fat cells in soft tissue, such as that inside the thigh or in the retroperitoneum. Pertumbuhannya cepat dan dapat ditemukan dalam ukuran yang besar.
Most phyllodes tumors are benign not cancerous, some are malignant cancerous, and some are borderline. Phyllodes tumors of the breast segregate in two groups. Analisis ekspresi cd117 dan ki67 pada tumor phyllodes benign majalah patologi fetty fatimah, sjahjenny mustokoweni, alphania rahniayu vol. Of course my doctor sent me for a mammy and ultrasound. Phyllodes tumours of the breast constitute an uncommon but fascinating group of fibroepithelial neoplasms that have a morphological resemblance to the intracanalicular fibroadenoma at the benign end of the spectrum, but with increased stromal cellularity and leaflike architecture. Tumor ini memiliki tekstur halus, berbatas tajam dan biasanya bergerak secara bebas. Its name is derived from the greek words sarcoma fleshy tumor, and phyllon leaf.
A very large phyllodes tumor may erode through overlying skin and present as an external fungating breast mass. Spindled component may be positive for high molecular weight keratin or p63. Pdf 11 212tumor phyllodes jurnal rinaldi zainuddin. Phyllodes tumor pt is an exceptionally rare breast neoplasm representing less. They are typically seen in women aged 35 to 55 years at presentation and are mostly large with a median size of 4 cm. Phyllodes tumors are rare, but they are usually benign. Tumor ini terdapat pada semua usia, tapi kebanyakan pada usia sekitar 45 tahun. Tumor filoides adalah tipe yang jarang dari tumor payudara, yang hampir sama dengan fibroadenoma yaitu terdiri dari dua jaringan, jaringan stroma dan glandular. If the phyllodes tumor of the breast is benign or borderline histology, radiation therapy not. Cystosarcoma phyllodes is a rare, predominantly benign tumor of the breast.
Jenis kanker payudara dari yang paling umum hingga yang langka. Meskipun ada kemungkinantumbuh membesar, namun fibroadenoma jenis ini biasanya akan mengecil dan menghilang seiring dengan berjalannya waktu. The histologic characteristics of the stroma and glands typically differ from one region to the next, and so does the relationship between these components fig. Case report open access anal phyllodes tumor in a male patient. Phyllodes tumor bears specific clinical characteristic and can be considered as a differential diagnosis for the breast lumps. Fibroadenoma merupakan salah satu jenis tumor jinak bukan kanker yang walaupun tidak mengancam nyawa tetapi harus tetap dipantau atau dilakukan terapi.
Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. February 22, 2011, neoplasia 1 lecture duke university. Sebagian besar tumor ini termasuk jinak, tapi 1 dari 4 kasusnya bisa bersifat kanker ganas. Bilateral and multifocal phyllodes tumours of the breast. Jika ditinjau dari distribusi penderita tumor payudara berdasarkan kelompok umur dan jenis kelamin, maka penyebaran data penelitian tumor payudara untuk tahun 20092010 adalah sebagai berikut. Between 1982 and 1998, 37 women with malignant phyllodes tumor were treated at the regional cancer center, trivandrum. Ppt phyllodes breast tumor powerpoint presentation. Ultrasonic elastography features of phyllodes tumors of the breast. Traditionally, phyllodes tumors are graded by the use of a set of histologic data into benign, borderline, and malignant. Insiden tumor phyllodes adalah jarang dan merupakan 0,31% dari tumor payudara wanita. Phyllodes adalah tumor payudara langka yang berkembang di jaringan ikat payudara. Malignant phyllodes tumour with metastasis to the lung. All specimens were believed to be phyllodes tumor based on a leaflike pattern in the epithelial component of the core biopsy.
Grading staging report phyllodes tumor of the breast. The excised tumor was circumscribed in shape, and after it was sliced into sections, it was noted that there were leaflike. Com phyllodes merupakan sebuah tumor dengan ciri benjolan keras pada jaringan stroma di payudara, tumor ini diperkirakan berkembang secara alami seiring dengan usia payudara bunda sendiri tumor phyllodes tergolong dalam tumor yang jinak atau harmless, namun bunda tidak boleh lengah dan menganggapnya remeh karena tumor ini sendiri dapat berubah ganas sewaktuwaktu. Borderline and malignant phyllodes tumours breast cancer now. This type of tumor is called a sarcoma, because it occurs in the connective tissue stroma of your breast, rather than in epithelial tissue lining of ducts and lobes. Case report open access anal phyllodes tumor in a male. A case report shane kf seal md frcsc, urve kuusk md frcsc, peter a lennox md frcsc department of surgery, division of plastic surgery, university of british columbia, vancouver, british columbia. Grossly, the tumor displays characteristics of a large, malignant sarcoma, takes on a leaflike appearance when sectioned, and displays epithelial, cystlike spaces when viewed histologically. Abstract phyllodes tumors is a rare fibroepithelial neoplasm. One month later i went for my second ultrasound on 9222011, and it was 3.
They tend to grow quickly, so theyre usually felt as a lump first. However, in the setting where additional recurrence would create significant. Scribd is the worlds largest social reading and publishing site. Lee and pack reported the first case of metastatic phyllodes tumor. Breastconserving surgery versus mastectomy for removal of phyllodes tumor has remained a bone of contention. Well teach you the best ways, using a mix of the market pdf file is about clinical immunology and serology a laboratory perspective clinical 5, take this time to introduce myself to you my, a pdf merger demoorder merge pdf files online free and easy to use.
It is typically a large, fast growing mass that forms from the periductal stroma of the breast. Phyllodes tumor pt of the breast are rare breast lesions, accounting for less than 1% of all breast tumors. I went to my doctor because i had a lump in my left breast, that grew very large, very rapidly. Patient, disease, and treatment factors were compared using log. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported. Haagensen melaporkan kirakira satu tumor filodes untuk setiap 40 fibroadenoma. Differential diagnosis phyllodes tumor of the breast. Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women.
Breast reconstruction was performed using a skin graft. Phyllodes tumor merging with invasive carcinoma of no special type h and e. Phyllodes breast tumor joint hospital surgical grand round 26 april 2014 ng yuen shan, sandy tuen mun hospital triple assessment, in patients with phyllodes tumors. Phyllodes tumor random reflections of a breast cancer surgeon. Jan 01, 2001 the study aims to evaluate the survival and prognosis of patients with malignant phyllodes tumor. They tend to grow quickly, but they rarely spread outside the breast. The patient received the same chemotherapy regimen as in the first case but without any response on her imaging follow up after 6 months. A 40 yearold white woman presented with threeweek history of pain and functional impairment of the left lower limb. Tumor ini adalah tumor yang relatif besar, dengan ukuran ratarata 5 cm. Apr 29, 2011 phyllodes tumors are uncommon and unpredictable. Malignant phyllodes tumor of the breast presenting with hypoglycemia. It causes a modest stimulation of breast fibroblast dna, but can combine with.
Stromal component negative for high molecular weight keratin and p63. Mar 20, 20 depending on the size of the breast and the location of the phyllodes tumor, mastectomy may also be required for tumors that are between 5 and 10 cm in diameter. Phyllodes tumors of the breast are uncommon fibroepithelial neoplasms, typified by hypercellular stroma and elongated ducts with irregular leaflike patterns due to stromal proliferation. Overlying skin may display a shiny appearance and be translucent enough to reveal underlying breast veins. Phyllodes tumor cystosarcoma phyllodes rare cancer. Cystosarcoma phyllodes adalah jarang, terutama tumor jinak yang terjadi hampir sematamata pada payudara wanita. The naming and classification of breast phyllodes tumor have been debated for years. In their least aggressive form, phyllodes tumors behave like benign fibroadenomas, although with a propensity to recur locally following excision without wide margins. Combining both cohorts, 42% of the pa tients were caucasian, 43% were hispanic, and 12% were black. Since phyllodes tumors are locally recurrent tumor especially when not excised with a clear margins and very u n p r e d i c t a b l ei ng r o w t ha n dm e t a s t a t i ca c t i v i t y,i ti sv. In certain areas, the proliferating fibroblasts of the phyllodes tumor remain confined to the specialized stromal compartment fig.
Adverse features stromal overgrowth one 40x field without epithelium. Ideal sources for wikipedia s health content are defined in the guideline wikipedia. Phyllodes tumors of the breast american cancer society. Lesions of anogenital mammarylike glands are rare, and only 44 female cases have been reported. The remaining 5 patients gave a history of pathologically documented fibrocystic disease. There were 36 phyllodes tumors 27 benign, 8 borderline, 1 malignant and. Menurut samsuhidajat 2004, tumor jinak payudara terdiri dari. Jul 07, 2018 scribd is the worlds largest social reading and publishing site. To be able to give an initial impression of the case to discuss the anatomy and physiology of the breast to differentiate benign from malignant breast mass to present on phyllodes tumor to identify appropriate management objectives. Sep 10, 2009 hey im 18 and ive been dx with phyllodes tumor.
They account for less than 1% of all breast tumors and display a wide range of biological behaviors, ranging from benign to highly aggressive. As malignant phyllodes tumors undergo mainly hematogenous spread, the proportion of patients with lymph node metastases are phyllodes tumors of the breast are rare, accounting for less than 1% of all breast tumors. Phyllodes tumor is a very rare type of breast tumor, which can be benign harmless or malignant cancerous. Arrows pointing to mitoses frequently talked about how many mitoses are seen on a high power field \40x field microscope\. Tumor phyllodes meski jarang wajib diwaspadai doktersehat. In conclusion, we report a malignant phyllodes tumor in an 11yearold girl, which recurred twice. Phyllodes tumors pts, which are rare and mostly benign in nature, are fibroepithelial tumors of the breasts. Hypothesis although phyllodes tumors have minimal metastatic potential, we hypothesized that they have a proclivity for local recurrence and should be excised with a wide margin. This lesion is also relatively small for a phyllodes tumor. Here are links to possibly useful sources of information about phyllodes tumor. My oncologist said its up to me if i want radiation, since its only recently being used more frequently for this type of cancer.
Calhoun and others published phyllodes tumors find, read and cite all the research you need on researchgate. Jul 23, 2019 the phyllodes tumors mammographic appearance, as a round density with smooth borders, is similar to that of fibroadenoma. Malignant phyllodes tumor is a rare and aggressive fibroepithelial neoplasm. Malignant phyllodes tumor of the breast in a 26yearold. Distribusi pada usia dibawah 20 tahun juga jarang, jika ada tampilan klinis dan histopatologinya adalah. They account for less than 1% of all breast neoplasms.
Malignant phyllodes tumor in an 11yearold girl with fatal. Phyllodes tumor is an uncommon biphasic breast tumor, with the ability to recur and metastasize, and it behaves biologically like a stromal neoplasm. Jul 23, 2019 curiously, phyllodes tumors tend to involve the left breast more commonly than the right. Phyllodes tumor is usually presented as a firm to hard, discrete, palpable mass, there is no clinical feature to distinguish benign or malignant phyllodes tumor from fibroadenoma5. The clinical presentation of this tumor is unilateral, and the behavior and management of this tumor are unclear. Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. Distribusi penderita tumor payudara berdasarkan kelompok. Herein, we describe a particularly rare case of phyllodes tumor of anogenital mammarylike glands in a 41yearold male presenting anal bleeding. The patient died of disease 3 years after initial surgical resection due to wide spread metastases. The clinical presentation of this tumor is unilateral, and the behavior and.
Thus, findings on imaging studies are not definitively diagnostic of phyllodes tumors. No single feature is reliable to predict clinical behavior of phyllodes tumors. Meski biasanya jinak, namun beberapa tumor phyllodes bisa saja berubah. With this technique, the image is obtained through gradual manual compression of. Phyllodes tumors journal of the american college of surgeons.
Jan 19, 20 phyllodes tumor bears specific clinical characteristic and can be considered as a differential diagnosis for the breast lumps. Sep 25, 2014 a very large phyllodes tumor may erode through overlying skin and present as an external fungating breast mass. The stroma is markedly cellular and the stromal cells show marked nuclear pleomorphism. These fragments display the wellbehaved structure of a fibroadenoma, and the organized pattern of these regions contrasts with the unruly appearance of the phyllodes tumor. Further study of how to combine sonography and ultrasound. Phyllodes tumors are rare fibroepithelial neoplasms that account for 0. The preoperative diagnosis and proper management are crucial in phyllodes tumor because of their tendency to recur and malignant potential in some of these tumors. The presence of leftover remnants of the fibroadenoma also contributes to the variability in the structure of phyllodes tumors fig. A low magnification of the primary breast phyllodes tumour with a cystic space into which stromal fronds projected. Phyllodes tumors are uncommon and unpredictable mayo clinic. Bab i pendahuluan latar belakang cystosarcoma phyllodes asalnya bisa dari fibroadenoma selular yang telah ada yang sekarang mengandung satu atau lebih komponen asal mesenkim. Pada umumnya, penyakit ini ditemukan pada wanita usia tumor ini biasanya berada di jaringan ikat yang dapat berkembang di salah satu payudara atau keduanya.
Although the stromal cellularity and atypia in some areas suggest a high grade malignant phyllodes tumor, most histological features are those of a lowgrade malignancy, including rare mitotic figures, alternating areas of hyprocellularity and a well circumscribed tumor border. Ini adalah jenis benjolan payudara yang paling umum ditemukan pada anak perempuan dan remaja berusia 1018 tahun. Phyllodes tumor random reflections of a breast cancer. Curiously, phyllodes tumors tend to involve the left breast more commonly than the right.
Phyllodes tumors are uncommon fibroepithelial breast tumors that are capable of a diverse range of biologic behaviors. I was referred to a general surgeon who said that because of the size of the tumor. Phyllodes tumors of the breast segregate in two groups according to. Phyllodes tumor is a rare fibroepithelial biphasic tumor of the breast. A retrospective database was queried for the patients diagnosed as phyllodes tumors and fibroadenomas at sun yatsen memorial hospital. Namanya berasal dari kata yunani sarcoma, yang berarti tumor berdaging.
While managing a giant phyllodes tumor, emphasis should be on complete extirpation of all visible tumors and breast tissue during mastectomy to minimize the chances of recurrence. Current trends in the management of phyllodes tumors of. Phyllodes tumors are uncommon and unpredictable mayo. Bone metastasis from malignant phyllodes breast tumor. Department of image, hospital ac camargo, sao paulo, sp, brazil. It is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope. Core needle biopsy as a diagnostic tool to differentiate. Distinction between phyllodes tumor and fibroadenoma in. A phyllodes tumor of the breast is a rare fibroepithelial tumor, accounting for 0. May 12, 2009 phyllodes tumor is an uncommon biphasic breast tumor, with the ability to recur and metastasize, and it behaves biologically like a stromal neoplasm. Phyllodes tumors of the breast are rare, accounting for less than 1% of all breast tumors. Open excisional breast biopsy for smaller lesions and incisional biopsy for large lesions are the definitive methods for diagnosing phyllodes tumors. Phyllodes tumors are rare breast tumors that start in the connective tissue and are most common in women in their 30s and 40s. This allows the pathologist to tell the clinician how badly the tumor is likely to behave.
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